For the first time, researchers have been working in a living human urinary tract that is capable of producing urine, suggesting that their findings are a milestone in research to improve kidney disease management.
Stem Cell Reports, published in a study by a laboratory of human embryonic stem cells, raised kidney globulins – vascular nuclei – mixed with a gel-like compound that is naturally occurring and then injected under the skin of mice, said medicalxpress.com.
Three months later, tissue examination results showed that nephrons that formed the base of the kidney were formed in mice. (The nephron kidney extract – formed by the vascular body and the so-called Bowman case – forms the primary filtrate which is converted into urine in the sewer system and is transmitted to the urinary tract.)
The nephrons formed had the decisive part of the nephrons in the human kidney, including the nearby (proximal) curved channel, the distal (curved) channel, the Bowman cages and the Henle cage.
Mice also developed capillaries associated with our own vascular system to nourish the new “mini-kidneys”. However, according to the researchers, without a large artery, the body can only carry a fraction of its total function. Researchers are now working with surgeons to work with the introduction of an artery to provide better blood supply to the “mini-excretory organs”.
To test the functionality of the small filter units, a fluorescent protein was used by the practitioners, which colored the urine-like substance through the blood filtration. Researchers have traced the pathway of the protein and have been shown in the “mini-kidney” channels, proving the filtration.
Professor Sue Kimber of the University of Manchester said that the functionality of the filtering units is proven, but it is not yet known how much the percentages are functioning.
“Dialysis or transplantation is used worldwide for 2 million people around the world due to kidney failure and, unfortunately, there are still two million deaths each year because they do not have access to these treatments,” said Professor Adrian Woolf, adding that their current discovery one day hopes to help treatment of patients.
The study was supported by the British Medical Research Council and the Kidney Research UK charity organization.